Shankhpushpi

<h3> Absolute Contraindications of Shankhpushpi </h3> <h4> Pregnancy (avoid) [Pregnant people]</h4> <ul> <li> 🤰</li> <li> Recommendation: Avoid using Shankhpushpi during pregnancy because human safety data are inadequate; consult an obstetrician before use.</li> <li> Reasoning: High-quality reviews note extensive animal and laboratory research but very limited clinical safety data in pregnant humans; when safety evidence is lacking, standard practice is to avoid non-essential herbal exposure in pregnancy.</li> <li> Scientific_Study_Title: Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies</li> <li> Scientific_Study_Authors: Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Baivab Sinha, Bairong Shen, Rohit Sharma</li> <li> Scientific_Study_Link: https://pubmed.ncbi.nlm.nih.gov/35878793/</li> <li> Scientific_Study_Excerpt: <p>Paraphrase: The umbrella review compiles pharmacology and toxicology data for C. pluricaulis and highlights that while many animal and in vitro experiments exist, clinical safety data-especially in vulnerable groups such as pregnant women-are sparse or absent.</p> <p>Short quoted text (≤25 words): "the plant profile, phytochemistry, neuropharmacological, and toxicological data" (from the review abstract).</p> </li> </ul> <h4> Breastfeeding (avoid) [Nursing people]</h4> <ul> <li> 🍼</li> <li> Recommendation: Avoid or discuss with a qualified provider before using while breastfeeding due to lack of controlled safety data for infants.</li> <li> Reasoning: Because systemic compounds can pass into breastmilk and there are no robust human studies documenting safety for infants, prudence recommends avoidance unless a clinician advises otherwise.</li> <li> Scientific_Study_Title: Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies</li> <li> Scientific_Study_Authors: Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Baivab Sinha, Bairong Shen, Rohit Sharma</li> <li> Scientific_Study_Link: https://pubmed.ncbi.nlm.nih.gov/35878793/</li> <li> Scientific_Study_Excerpt: <p>Paraphrase: The review highlights the lack of targeted human safety trials in special populations (pregnancy, lactation), meaning evidence for safety in breastfeeding is insufficient.</p> <p>Short quoted text (≤25 words): "the crude herb and its metabolites have exhibited... neuropharmacological effects" (context: limited human safety data noted).</p> </li> </ul> <h4> Concurrent use with strong sedatives / anaesthetic agents [When receiving anesthesia or strong sedating drugs]</h4> <ul> <li> ⚠️</li> <li> Recommendation: Do not take Shankhpushpi before surgery or with strong sedatives/anaesthetics unless approved by the anaesthesiologist; it may increase sedation.</li> <li> Reasoning: Animal studies demonstrate CNS-depressant and muscle-relaxant effects; combined use with other depressants could produce excessive sedation or impaired respiratory/psychomotor function.</li> <li> Scientific_Study_Title: Evaluation of CNS Depressant and Anti-anxiety Activities of Leaves of Convolvulus pluricaulis</li> <li> Scientific_Study_Authors: (authors as listed on PubMed entry)</li> <li> Scientific_Study_Link: https://pubmed.ncbi.nlm.nih.gov/36825716/</li> <li> Scientific_Study_Excerpt: <p>Paraphrase: In mice, hydroalcoholic leaf extract showed dose-dependent CNS-depressant and anxiolytic effects (reduced locomotion, changes in maze behaviour), and acute toxicity testing placed it in a category consistent with sedative potential.</p> <p>Short quoted text (≤25 words): "showed CNS depressant and anti-anxiety effects" (from abstract).</p> </li> </ul> <h3> Relative Contraindications of Shankhpushpi </h3> <h4> People on antiepileptic medications [Taking seizure medicines]</h4> <ul> <li> ⚖️</li> <li> Recommendation: Discuss with your neurologist before adding Shankhpushpi-monitor seizure control and drug levels if recommended.</li> <li> Reasoning: Preclinical data show anticonvulsant activity and additive effects with anticonvulsant drugs in animals; this suggests the herb can modify seizure thresholds or interact with antiepileptic drug action.</li> <li> Scientific_Study_Title: Anticonvulsant activity of Shankhapuspi (Convolvulus pluricaulis Chois) on Strychnine induced seizure in experimental animals</li> <li> Scientific_Study_Authors: Kshirod Kumar Ratha, Sthiti Srujani Mishra</li> <li> Scientific_Study_Link: https://www.ijam.co.in/index.php/ijam/article/view/163</li> <li> Scientific_Study_Excerpt: <p>Paraphrase: The study found that aqueous extract possessed anticonvulsant activity and that co-administration with phenytoin produced significant anticonvulsant effects versus phenytoin alone in animal models-implying potential pharmacodynamic interaction.</p> <p>Short quoted text (≤25 words): "results... suggested that Shankhapuspi can be prescribed as a co-therapeutic agent of Phenytoin"</p> </li> </ul> <h4> People on cholinesterase inhibitors (e.g., dementia drugs) [Taking donepezil, rivastigmine]</h4> <ul> <li> 🧠</li> <li> Recommendation: If you take AChE inhibitor medication, consult your clinician-Shankhpushpi may modify cholinergic activity and could change symptom control or side effects.</li> <li> Reasoning: Animal models show Convolvulus extracts influence AChE activity and cholinergic markers (restoring depleted AChE activity in some models), so combined effects with cholinesterase drugs may alter therapeutic response.</li> <li> Scientific_Study_Title: In vivo investigation of the neuroprotective property of Convolvulus pluricaulis in scopolamine-induced cognitive impairments in Wistar rats</li> <li> Scientific_Study_Authors: (authors as listed on PubMed entry)</li> <li> Scientific_Study_Link: https://pubmed.ncbi.nlm.nih.gov/22021993/</li> <li> Scientific_Study_Excerpt: <p>Paraphrase: Pretreatment with aqueous extract reduced scopolamine-induced cognitive deficits and influenced acetylcholinesterase and antioxidant parameters, consistent with modulation of cholinergic function.</p> <p>Short quoted text (≤25 words): "administration of extract improved the impairment of spatial memory" (from abstract).</p> </li> </ul> <h4> People on serotonergic antidepressants or MAO inhibitors [Taking SSRIs, SNRIs, MAOIs]</h4> <ul> <li> ⚠️🧪</li> <li> Recommendation: Use caution and consult your prescribing clinician-there is theoretical potential for interaction via serotonergic and monoamine pathways.</li> <li> Reasoning: Network pharmacology studies identify targets such as MAOA/MAOB and serotonergic synapses among predicted interactions for Shankhpushpi phytochemicals; this suggests possible additive or modulatory effects on monoamine systems.</li> <li> Scientific_Study_Title: Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach</li> <li> Scientific_Study_Authors: Md. Abdul Hannan et al.</li> <li> Scientific_Study_Link: https://pubmed.ncbi.nlm.nih.gov/36225186/</li> <li> Scientific_Study_Excerpt: <p>Paraphrase: The computational analysis found major active constituents that could target proteins including MAOA/MAOB and serotonin-related pathways-supporting a plausible interaction with serotonergic drugs.</p> <p>Short quoted text (≤25 words): "target proteins such as PTGS1, PTGS2, NOS3, PPARG, ACHE, MAOA, MAOB..."</p> </li> </ul>